You, Me and Dupree - Cast

Owen Wilson

Dupree
Actor

Kate Hudson

Molly
Actor

Matt Dillon

Carl
Actor

Michael Douglas

Mr. Thompson
Actor

Seth Rogen

Neil
Actor

Amanda Detmer

Annie
Actor

Todd Stashwick

Tony
Actor

Bill Hader

Mark
Actor

Lance Armstrong

Lance Armstrong
Actor

Jason Winer

Eddie
Actor

Sidney S. Liufau

Paco
Actor

Billy Gardell

Bartender Dave
Actor

Suzanne Ford

Thompson's Secretary
Actor

Claudia Choi

Carl's Secretary
Actor

Summer Altice

Stripper
Actor

Joe Russo

Personnel Manager
Actor

Lance Irwin

Neighborhood Father
Actor

Fenessa Pineda

2nd Grade Girl
Actor

Mario Revolori

2nd Grade Boy
Actor

Gil Harris

Reese
Actor

Pat Crawford Brown

Aunt Kathy
Actor

Bayani Ison

Hawaiian Bartender
Actor

Kevin Breznahan

Charlie
Actor

Craig Hosking

Pilot
Actor

Harry Dean Stanton

Curly (uncredited)
Actor

Amber Hay

Wedding Guest (uncredited)
Actor

Michelle Lee

Hawaiian Air Ticketing Agent (uncredited)
Actor

Tasha Smith

Co-Worker (uncredited)
Actor