Osmosis Jones - Cast

Chris Rock

Osmosis Jones (voice)
Actor

Laurence Fishburne

Thrax (voice)
Actor

David Hyde Pierce

Drix (voice)
Actor

Brandy Norwood

Leah (voice)
Actor

Elena Franklin

Shane Detorre
Actor

Bill Murray

Frank Detorre
Actor

William Shatner

Mayor Phlegmming (voice)
Actor

Ron Howard

Tom Colonic (voice)
Actor

Kid Rock

Kidney Rock (voice)
Actor

Molly Shannon

Mrs. Boyd
Actor

Chris Elliott

Bob
Actor

Jonathan Adams

Officer Tom (voice)
Actor

Carlos Alazraqui

Spanish Germ (voice)
Actor

Eddie Barth

Conductor (voice)
Actor

Sally Brooks

Additional Character Voices (voice)
Actor

Rodger Bumpass

Joe Cramp / Announcer for Nerve News Network (voice)
Actor

Janis Dardaris

Additional Character Voices (voice)
Actor

Antonio Fargas

Chill the Flu Shot (voice)
Actor

Eddie Frierson

Frank Police Department Officer (voice)
Actor

Donald Fullilove

Doughnut (voice)
Actor

Jackie Gonneau

Additional Character Voices (voice)
Actor

Richard Steven Horvitz

Additional Character Voices (voice)
Actor

Rif Hutton

Charlie (voice)
Actor

Anne Lockhart

Female Red Blood Cell (voice)
Actor

Sherry Lynn

Trudy (voice)
Actor

Danny Mann

Musician Cell (voice)
Actor

Mickie McGowan

Brain Librarian (voice)
Actor

Joel Silver

Police Chief (voice) (uncredited)
Actor

John Melendez

Artie (voice)
Actor

Héctor Mercado

Additional Character Voices (voice)
Actor

Paul Pape

Male Red Blood Cell #2 (voice)
Actor

Chris Phillips

Firefighter Doug (voice)
Actor

Al Rodrigo

Frank Police Department Walkie Talkie (voice)
Actor

Herschel Sparber

Bruiser (voice)
Actor

Keri Tombazian

Additional Character Voices (voice)
Actor

Paul Tuerpe

Additional Character Voices (voice)
Actor

Robert Wisdom

Big Germ (voice)
Actor

Danny Murphy

Zookeeper Superintendent
Actor

Jackie Flynn

School Janitor
Actor

Abe Farrelly

Bus Girl #2
Actor

Kevin J. Flynn

Docky's Clamshack Waiter
Actor

Sean Gildea

Dreamy Photographer
Actor

Nikki Tyler-Flynn

Nurse #2
Actor

Zen Gesner

ER Doctor #1
Actor

Zak Penn

ER Doctor #3
Actor